Polyglutamic Acid

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Cat Number

CIA25513466

CAS Number

25513-46-6

For research use only. We do not supply to patients.

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CAS Number

25513-46-6

EINECS

200-293-7

Storage

Store at -20℃

Synonyms

L-Glutamic acid polymer; gamma-L-Polyglutamic acid

Molecular Formula

C5H9NO4

Molecular Weight

147.13

Smiles

C(CC(=O)O)[C@@H](C(=O)O)N

Appearance

White powder

General Description

Polyglutamic acid (PGA) is a homo-polyamide made up of D- and L- Glutamic acid monomers linked by amide linkages between the α-amino and the γ-carboxyl group. It is therefore protease-resistant. PGA is an optically active biopolymer with a chiral centre present in every glutamate unit. PGA, this anionic polypeptide has a unique feature of glutamate polymerized through γ-amide linkage, which can be easily synthesized by various microorganisms.

Application

Polyglutamic acid is used in cosmetics, medicine and environmental protection. Cosmetically, it functions as a "hydrogel" in high-end serums designed to improve skin hydration and plumping. In medicine, PGA's low immunogenicity allows it to function as a carrier for drug delivery systems and tissue engineering scaffolds. In addition to these applications in health care, PGA has environmental applications as well, including a biodegradable flocculant that removes heavy metals from wastewater treatment plants and as a plant biostimulant to promote crop yields in times of drought.

An amphipathic polyglutamic acid (PGA)-based formulation of amphotericin B (AmB) was prepared by self-assembly. AmB-loaded PGA nanoparticles (98±2 nm; zeta potential: -35.2±7.3 mV) displayed high stability in PBS and serum (<20% release after 10 days), lower hemolytic toxicity (≤15% lysis at 100 µg/mL) and preserved antifungal potency compared to Fungizone. Cell viability of mammalian cells determined by MTT assay showed no cytotoxicity at 200 µg/mL and no kidney necrosis was observed by histopathology. The formulation also demonstrated potent activity against C. albicans and inhibited biofilm formation comparable to Fungizone. These PGA nanoparticles encapsulating AmB show promise to retain antifungal activity while minimizing toxicity.

Fig. 2 Scanning electron micrographs of inhibition of Candida albicans biofilm mediated by the AmB–PGA formulation. (Urimi D, et al. 2019)

References

Urimi D, et al. Polyglutamic acid functionalization of chitosan nanoparticles enhances the therapeutic efficacy of insulin following oral administration. AAPS PharmSciTech. 2019, 20(3): 131.

Does Polyglutamic Acid need protection from light?

Yes, store Polyglutamic Acid in light-resistant containers to prevent any potential UV-induced degradation of the polymer.

How should I handle a container of Polyglutamic Acid after opening?

Re-seal the Polyglutamic Acid container immediately after use to minimise exposure to atmospheric moisture and contaminants.

How do I request a quote for Polyglutamic Acid?

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Will I receive a tracking number for Polyglutamic Acid?

We provide a tracking link as soon as the Polyglutamic Acid shipment leaves our warehouse facility.