Polixetonium Chloride

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Cat Number

CHE31512740

CAS Number

31512-74-0

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Product Detail Description Scientific Support Customer Q&A

CAS Number

31512-74-0

EINECS

200-769-4

Storage

Refrigerator, under inert atmosphere

Synonyms

Poly[oxyethylene(dimethylimino) ethylene(dimethylimino) ethylene dichloride]; N-(2-Methoxyethyl)-N,N,N',N'-tetramethyl-N'-propyl-1,2-ethanediaminium dichloride; Poly(oxyethylene(dimethylimino)ethylene(dimethylimino)ethylene dichloride)

Molecular Formula

C10H24N2OX2.2Cl

Molecular Weight

259.22

Appearance

Pale yellow oil

General Description

Polixetonium Chloride is a powerful polymeric quaternary ammonium salt. A non-foaming cationic surfactant, it is an effective antimicrobial agent. Because of its excellent water solubility and stable characteristics over a wide pH spectrum, Polixetonium Chloride is used extensively as an industrial strength biocide and clarifier in water treatment and industrial process water systems.

Mechanism of Action

The antimicrobial action of Polixetonium Chloride is attributed to its high charge density along the polymer backbone. Positively charged sites within Polixetonium Chloride are attracted to the cell walls of microbes by way of an electrostatic interaction. The negatively charged cell membrane allows Polixetonium Chloride to breach the semi-permeable integrity of the cell wall structure. This breach causes the cell contents to leak out of the microbial cell and ultimately causes cell death. Because Polixetonium Chloride is a polymeric quaternary ammonium compound it will not produce foam thus allowing hydraulic efficiency in closed-loop systems.

Application

Polixetonium Chloride is the active ingredient in many swimming pool/spa algaecides and cooling tower formulations used to control hard-to-treat green, black, and mustard algae. Used extensively as a clay stabilizer and biocide in oilfield water flooding systems to prevent MIC. Polixetonium chloride is also used as an industrial strength flocculant and preservative in metalworking fluids, paper processing, and textile processing applications.

SH-SY5Y/astrocyte co-cultures were employed, alongside automated high-content image analysis, to assess the neurotoxic potential of a group of twelve biocidal disinfectants in vitro. Polixetonium chloride displayed no detectable neurotoxic activity in differentiated SH-SY5Y/astrocyte co-cultures. Total neurite length, branching and cell number were unaffected by treatment with 1-10 µg per mL. A slight but significant decrease in neurite outgrowth was seen in monocultures of SH-SY5Y cells treated with the same compound at 2.5 µg per mL, with no change in cell viability. It is likely that astrocytes confer some resistance to polixetonium chloride toxicity, and that its neurotoxic effects are weak or nonexistent under acute exposure conditions.

Fig. 1 SH‑SY5Y/astrocyte co‑culture system for Polixetonium Chloride neurotoxicity assessment. (Oh H N.; et al. 2022)

References

Oh H N.; et al. In vitro neurotoxicity evaluation of biocidal disinfectants in a human neuron-astrocyte co-culture model. Toxicology in Vitro, 2022, 84: 105449.

Will Polixetonium Chloride react with chlorine?

No, Polixetonium Chloride will remain stable with chlorine and other oxidizing sanitizers.

What pH range is Polyxetronium chloride effective in?

Polixetonium chloride works over a wide range of pH values. Most systems will be between pH 4.0 - 10.0.

How does Polixetonium Chloride clarify water?

Polixetonium Chloride is what is known as a cationic polymer. Adding it to water will neutralize the charge of microscopic suspended particles. Once the charge is neutralized these particles will begin to coagulate, or clump together.

What is the recommended storage condition?

Keep the container tightly closed in a cool dry place. Do not freeze.