PHORBOL 12-MYRISTATE 13-ACETATE

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Cat Number

PIPE-0514

CAS Number

16561-29-8

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Product Detail

CAS Number

16561-29-8

EINECS

605-413-5

Storage

Room temperature

Synonyms

Phorbol 12-myristate 13-acetate phorbol-12-myristate-13-acetate 12-O-Tetradecanoylphorbol-13-acetate 12-O-Tetradecanoylphorbol 13-acetate

Description

It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types. It has a role as a protein kinase C agonist, an antineoplastic agent, a reactive oxygen species generator, a plant metabolite, a mitogen, a carcinogenic agent and an apoptosis inducer. It is an acetate ester, a tetradecanoate ester, a diester, a tertiary alpha-hydroxy ketone and a phorbol ester.

Molecular Formula

C36H56O8

Molecular Weight

616.8

Appearance

white crystals

Melting Point

50-70 ℃ (melting pt-freezing pt)

Boiling Point

698.1±55.0℃ at 760 mmHg

Purity

HPLC≥98%