Perflexane

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Cat Number

API355420

CAS Number

355-42-0

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Product Detail Description Advanced Innovations Customer Q&A

CAS Number

355-42-0

EINECS

206-585-0

Synonyms

Perfluorohexane

Molecular Formula

C6F14

Molecular Weight

338.04

Smiles

C(C(C(C(F)(F)F)(F)F)(F)F)(C(C(F)(F)F)(F)F)(F)F

Appearance

Colorless liquid

Melting Point

4℃

Boiling Point

58-60℃

Relative Density

1.67

General Description

Perflexane (perfluorohexane, C6F14) is a fully fluorinated alkane belonging to the class of perfluorocarbon (PFC) compounds. All hydrogen atoms are replaced by fluorine, giving it exceptional chemical inertness, very high gas-dissolving capacity, and extreme hydrophobicity. It is the active component in certain ultrasound contrast agent formulations.

Mechanism of Action

As a perfluorocarbon liquid, perflexane encapsulated in microspheres provides acoustic contrast by reflecting ultrasound waves at gas-liquid interfaces. Perfluorocarbon compounds dissolve high volumes of respiratory gases (O2, CO2) and can serve as oxygen carriers in hemoglobin-free perfusion research.

Application

Used as the active gas core in ultrasound contrast agent formulations for echocardiography and vascular imaging. Perflexane is a perfluorocarbon compound with exceptional acoustic reflectivity and gas stability, providing enhanced ultrasound signal for improved cardiac chamber and blood flow visualization.

Lipid nanoparticles encapsulating perflexane were prepared using a thin-film hydration-ultrasonication technique and coated with medullary thyroid carcinoma cell membrane to create biomimetic nanoparticles with active targeting capability. The nanoparticles exhibited a core-shell structure with diameter of 131.06 nm and zeta potential of -30.59 mV. Upon stimulation with low-intensity focused ultrasound, the perflexane-containing nanoparticles underwent phase transition, forming microbubbles with ultrasound signal intensity peaking at 4 minutes. Following ultrasound irradiation, the nanoparticles produced cytotoxic reactive oxygen species, effectively killing medullary thyroid carcinoma cells and inhibiting their migration.

Fig. 2 TEM images of HP@LNP and MHP@LNP nanoparticles. (Zhu W.; et al. 2025)

References

Zhu W, et al. Dual-modality imaging bionic nanoparticles for sonodynamic therapy on medullary thyroid carcinoma. Chinese Journal of Tissue Engineering Research, 2025, 29(16): 3410.

What properties make Perflexane useful in ultrasound contrast agents?

Perflexane's high acoustic impedance mismatch with biological fluids, low water solubility ensuring gas stability in microbubbles, and exceptional biocompatibility make it ideal for echogenic microsphere formulations.

What purity grade is available?

Supplied as a high-purity grade suitable for medical imaging R&D and pharmaceutical manufacturing.

Can packaging be customized?

Packaging formats and order quantities are customizable upon request for R&D and production needs.

Is international shipping available?

Available for supply to customers in most countries and regions worldwide.