Pemoline

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Cat Number

API0231608

CAS Number

2152-34-3

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Product Detail Description Customer Q&A

CAS Number

2152-34-3

EINECS

218-438-8

Storage

Store at room temperature

Synonyms

Phenoxazole; Azoksodon; Phenylisohydantoin; Tradon; Azoxodon

Molecular Formula

C9H8N2O2

Molecular Weight

176.17

Smiles

C1=CC=C(C=C1)C2C(=O)N=C(O2)N

Appearance

White crystalline powder

Melting Point

255-256℃

Boiling Point

313.6℃ at 760 mmHg

Relative Density

1.4

General Description

Pemoline is a central nervous system stimulant that was previously approved for the treatment of attention-deficit/hyperactivity disorder (ADHD). It is a non-amphetamine, oxazolidinone derivative with a longer duration of action than methylphenidate.

Mechanism of Action

Pemoline is believed to increase dopamine and norepinephrine levels in the prefrontal cortex and striatum, similar to other ADHD medications, though its precise mechanism is less well-characterized. It acts as a weak dopamine reuptake inhibitor and may also enhance dopaminergic release. Unlike amphetamines, it does not block the vesicular monoamine transporter. The drug has a slow onset (3-4 weeks for full effect) and a plasma half-life of approximately 12 hours.

Application

Historically, pemoline was indicated for ADHD in children and adolescents as a second-line agent when other stimulants were ineffective or poorly tolerated.

Does Pemoline require protection from light during long-term storage?

Yes, it is photosensitive. UV light can cause photodegradation and discoloration. Store in light-resistant, tightly sealed containers, preferably amber glass.

What is the recommended storage temperature for Pemoline?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which can accelerate decomposition of the oxazolidinone ring.

Is Pemoline stable under high-humidity conditions?

It is slightly hygroscopic. Under high humidity (>70% RH), it may absorb moisture and clump, but chemical hydrolysis is minimal. Store with desiccant for long-term stability.

How is the impurity 2-amino-5-phenyl-2-oxazoline-4-one monitored?

This process-related impurity is quantified using a stability-indicating HPLC method, ensuring it remains below USP limits.