Pectin

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Cat Number

PIE-0349

CAS Number

9000-69-5

For research use only. We do not supply to patients.

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Product Detail Description Advanced Innovations Customer Q&A

CAS Number

9000-69-5

EINECS

232-553-0

Molecular Formula

(C6H10O7)n

Appearance

Powder

General Description

Pectin is a naturally occurring polysaccharide present in the cell walls of plants. It is mainly extracted from citrus peel and apple pomace. Pectin is comprised mainly of D-galacturonic acid polymerized units joined through alpha-1,4 linkages. Its primary functional property is its degree of esterification (DE), and depending on DE, pectin is either categorized as a High Methoxyl or Low Methoxyl pectin. The DE directly affects the way that pectin gels.

Application

Pectin is commonly used in the food industry as gelling agent for jams, jellies, and fruit preserves. It also acts as a stabilizer in dairy-based foods (yogurts, desserts) and beverages based on fruit pulp. Pectin is used in products with reduced sugar content or sugar-free varieties to create texture in food. Pectin is also commonly used as a pharmaceutical binder in tablet coatings, in encapsulation of targeted drug delivery systems as well as in wound healing dressings. Pectin is commonly used to increase viscosity of cosmetic creams. It is also used as a film-forming agent in edible packaging. In nutraceuticals, it is used as a soluble dietary fiber.

The efficacy of an oral-targeted drug delivery system (OTDDS) of oxymatrine (OMT) in UC treatment was investigated. Nanoparticles (OMT/SA-NPs) were prepared using OMT, pectin, Ca²⁺, chitosan (CS), and sialic acid (SA). The average particle size of OMT/SA-NPs was found to be 255.0 nm with a zeta potential value of −12.4 mV. The drug loading capacity and encapsulation efficiency were high at 14.65% and 84.83%, respectively. OMT/SA-NPs remained stable throughout the GIT and successfully targeted the delivery of OMT to the colon. OMT/SA-NPs showed excellent biocompatibility, anti-inflammatory activity, and dose- and time-dependent uptake by RAW 264.7 cells through SA-mediated endocytosisin vitro. OMT/SA-NPs also exhibited stronger anti-inflammatory and anti-colitis efficacy in vivo compared to free OMT due to (1) effective delivery of the drug to the colon and (2) site-specific targeting/internalization and prolonged retention mediated by SA (3) anti-inflammatory activity of both OMT and nanoparticles.

Fig. 2 Schematic illustration of using OMT/SA-NPs in the treatment of UC in mice. (Zhao C, et al. 2024)

References

Zhao C, et al. The investigation on sialic acid-modified pectin nanoparticles loaded with oxymatrine for orally targeting and inhibiting the of ulcerative colitis. Colloids and Surfaces B: Biointerfaces. 2024, 236: 113809.

How is high-methoxyl (HM) pectin different from low-methoxyl (LM) pectin?

HM pectin requires high sugar/acid to gel, while LM pectin gels with calcium ions, enabling low-sugar applications.

How does pH affect pectin’s gelling capability?

Pectin gels optimally at pH 2.8–3.5; higher pH reduces gel strength due to electrostatic repulsion.

How should bulk pectin powder be stored?

Store in airtight containers at ≤25°C with ≤50% humidity to prevent caking and degradation.

How do I receive the tracking number for Pectin?

Your Pectin tracking number will be emailed immediately following shipment dispatch.