Paramethadione

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Cat Number

API0231567

CAS Number

115-67-3

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Product Detail Description Customer Q&A

CAS Number

115-67-3

EINECS

204-098-8

Storage

Store at room temperature

Synonyms

Paradione; Isoethadione; 5-Ethyl-3,5-dimethyl-1,3-oxazolidine-2,4-dione; Paramethadionum; 2,4-Oxazolidinedione, 5-ethyl-3,5-dimethyl-; Parametadiona; 3,5-Dimethyl-5-ethyloxazolidine-2,4-dione; 5-Ethyl-3,5-dimethyl-2,4-oxazolidinedione

Molecular Formula

C7H11NO3

Molecular Weight

157.17

Smiles

CCC1(C(=O)N(C(=O)O1)C)C

Appearance

Clear colorless liquied

Melting Point

31-32℃

Boiling Point

281.82℃

Relative Density

1.124

General Description

Paramethadione is an anticonvulsant belonging to the oxazolidinedione class, chemically and pharmacologically similar to trimethadione. It is a small molecule drug that acts on the central nervous system to control absence seizures.

Mechanism of Action

Paramethadione is a dione anticonvulsant that reduces T-type calcium currents in thalamic neurons, including thalamic relay neurons. This reduction inhibits corticothalamic transmission and raises the threshold for repetitive activity in the thalamus. The dampening of abnormal thalamocortical rhythmicity is proposed to underlie its efficacy against the 3-Hz spike-and-wave discharge seen on EEG during absence seizures.

Application

It is used for the control of absence (petit mal) seizures that are refractory to treatment with other medications. Paramethadione is not generally a first-line agent due to its teratogenic risks and the availability of safer alternatives. Its use requires careful consideration of the benefit-risk profile, particularly in females of childbearing potential.

Does Paramethadione require refrigerated storage as an oxazolidinedione anticonvulsant?

No, it is stable at controlled room temperature (15-25°C). Refrigeration is not required, but avoid excessive heat above 30°C to prevent volatilization, as it is a liquid.

Is Paramethadione sensitive to light, and how should it be handled?

It is moderately photosensitive. Store in light-resistant, tightly sealed containers, preferably amber glass, to prevent photodegradation and discoloration.

What packaging is recommended for shipping Paramethadione to prevent leakage?

We use glass ampules or aluminum bottles with PTFE-lined screw caps, sealed under inert gas, to prevent leakage and oxidation during transport.

How is the impurity 5,5-dimethyl-2,4-oxazolidinedione controlled?

This process-related impurity is quantified using a validated GC or HPLC method, ensuring it remains below pharmacopoeial limits throughout shelf life.