Nilutamide

Inquiry

Cat Number

API63612500

CAS Number

63612-50-0

For research use only. We do not supply to patients.

For pharmaceutical-grade products or other inquiries, please contact our experts.

Product Detail Description Customer Q&A

CAS Number

63612-50-0

EINECS

624-700-6

Storage

Store at room temperature

Synonyms

Anandron; Nilandron; 5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)imidazolidine-2,4-dione; Nilutamida; Nilutamidum; RU-23908

Molecular Formula

C12H10F3N3O4

Molecular Weight

317.22

Smiles

CC1(C(=O)N(C(=O)N1)C2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)C

Appearance

Almost white crystalline powder

Melting Point

153-156°C

Relative Density

1.463±0.06 (Predicted)

General Description

Nilutamide is a nonsteroidal antiandrogen with a hydantoin core, a trifluoromethyl group, and a nitro group, structurally related to flutamide. Its chemical structure is 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione.

Mechanism of Action

Nilutamide acts as a competitive antagonist at the androgen receptor, blocking the binding of testosterone and dihydrotestosterone to the receptor. This prevents androgen-induced gene expression, inhibiting the growth of prostate cancer cells. Unlike GnRH agonists, nilutamide does not cause an initial flare reaction, making it suitable for use in combination with surgical or medical castration.

Application

Nilutamide is indicated for the treatment of metastatic prostate cancer, in combination with surgical castration or GnRH agonists. It is used to block the effects of adrenal androgens, contributing to the suppression of tumor growth.

Does Nilutamide require protection from light during long-term storage?

Yes, it is photosensitive. Light exposure can cause photodegradation and discoloration of the imidazolidine ring. Store in light-resistant containers, preferably amber glass.

What is the recommended storage temperature for Nilutamide?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which can accelerate oxidation and degradation.

Is Nilutamide hygroscopic, and how is this managed?

It is slightly hygroscopic. Under high humidity (>70% RH), it may absorb moisture and clump. Storage in tightly sealed containers with desiccant is recommended.