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N-Fmoc-N-methyl-O-benzyl-L-serine

N-Fmoc-N-methyl-O-benzyl-L-serine

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Cat Number
INT84000146
CAS Number
84000-14-6

If you have any other questions, please contact our experts.

CAS Number
84000-14-6
Storage
2-8℃
Synonyms
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-O-BENZYL-L-SERINE
Molecular Formula
C26H25NO5
Molecular Weight
431.48
Smiles
CN([C@@H](COCC1=CC=CC=C1)C(=O)O)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
Appearance
White to off-white solid
Boiling Point
618.9℃
pKa
3.43
General Description
N-Fmoc-N-methyl-O-benzyl-L-serine is a highly protected serine derivative featuring both N-methylation and benzyl ether protection on the side-chain hydroxyl group.
Mechanism of Action
It provides dual protection for peptide synthesis. The N-methyl group modifies the backbone, while the benzyl group (OBzl) is an orthogonal protector that remains stable during Fmoc deprotection steps but can be removed by hydrogenation.
Application
It is a valuable tool for the synthesis of modified serine-containing peptides, specifically those requiring late-stage side-chain modification or high structural rigidity.

How to store N-Fmoc-N-methyl-O-benzyl-L-serine?

It should be kept in a cool area and protected from moisture and air.

Can the O-benzyl group in N-Fmoc-N-methyl-O-benzyl-L-serine be removed?

Yes, it can be removed via catalytic hydrogenation to yield the free alcohol.

Does it follow international standards?

Yes, our manufacturing for it follows strict international industry standards.

Are SDS available for N-Fmoc-N-methyl-O-benzyl-L-serine?

Yes, a detailed SDS is provided for it with each order.

Is N-Fmoc-N-methyl-O-benzyl-L-serine soluble in DMSO?

Yes, it is soluble in most common polar organic solvents used in synthesis.
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