N-[4,5,6,7-TetrahydrobenziMidazole-5-yl)carbonyl] pyrrolidine sulfate

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Cat Number

INT132036421

CAS Number

132036-42-1

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Product Detail Description Customer Q&A

CAS Number

132036-42-1

Storage

2-8℃

Synonyms

1-[(4,5,6,7-Tetrahydro-1H-benzimidazol-5-yl)carbonyl]pyrrolidine monohydrochloride;1-Pyrrolidinyl(4,5,6,7-tetrahydro-1H-benzimidazol-6-yl)methanone hydrochloride

Molecular Formula

C12H17N3O.ClH

Molecular Weight

255.75

Smiles

C1CC2=C(NC=N2)CC1C(N1CCCC1)=O.Cl

General Description

N-[4,5,6,7-Tetrahydrobenzimidazole-5-yl)carbonyl] pyrrolidine sulfate is a fused bicyclic tetrahydrobenzimidazole intermediate linked via an amide bond to a pyrrolidine ring, formulated as the sulfate salt. The tetrahydrobenzimidazole core is a partially saturated benzimidazole ring, and the pyrrolidine substituent provides a basic amine functionality. The sulfate salt enhances aqueous solubility and provides a stable, crystalline solid suitable for handling and storage.

Mechanism of Action

This compound functions as a fused heterocyclic intermediate in pharmaceutical synthesis. The tetrahydrobenzimidazole core retains the metal-chelating and hydrogen-bonding properties of the benzimidazole scaffold while the saturated (tetrahydro) ring introduces stereogenic centers. The amide bond is chemically stable, and the pyrrolidine nitrogen is available for further alkylation or acylation reactions. The sulfate counterion improves water solubility compared to the free base.

Application

N-[4,5,6,7-Tetrahydrobenzimidazole-5-yl)carbonyl] pyrrolidine sulfate is used as an intermediate in the synthesis of benzimidazole-based pharmaceuticals including proton pump inhibitors (PPIs), H2-receptor antagonists, and anti-helmintic agents (albendazole, mebendazole analogs). The tetrahydro substitution provides additional target selectivity in certain ATP-competitive kinase inhibitors. The pyrrolidine amide may be a precursor to peptidomimetic structures.

What is the recommended storage condition for N-[4,5,6,7-TetrahydrobenziMidazole-5-yl)carbonyl] pyrrolidine sulfate?

It should be stored at 2-8°C in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Is a Certificate of Analysis (COA) available for N-[4,5,6,7-TetrahydrobenziMidazole-5-yl)carbonyl] pyrrolidine sulfate?

Yes, a fully verified COA is issued for every batch and can be shared electronically. Additional documentation such as MSDS or impurity profiles may be requested separately.

Is N-[4,5,6,7-TetrahydrobenziMidazole-5-yl)carbonyl] pyrrolidine sulfate available in high-chemical-purity grade for pharmaceutical synthesis?

Yes, it is supplied in high chemical purity grades suitable for demanding pharmaceutical intermediate applications. Specifications and analytical data are available upon request.

Can N-[4,5,6,7-TetrahydrobenziMidazole-5-yl)carbonyl] pyrrolidine sulfate be provided with custom specifications for synthetic applications?

Custom specifications including adjusted particle size, solvent residue limits, or additional purity testing can be arranged for qualified customers with defined requirements.

Does your company offer custom packaging for N-[4,5,6,7-TetrahydrobenziMidazole-5-yl)carbonyl] pyrrolidine sulfate?

Yes, custom pack sizes are available. Specific quantity requirements can be discussed directly with our team to align with your production or research scale.