Metrizoate Meglumine

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Cat Number

API0231639

CAS Number

7241-11-4

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Product Detail Description Customer Q&A

CAS Number

7241-11-4

EINECS

230-641-3

Storage

Store at room temperature

Synonyms

Methylglucamine metrizoate; UNII-RJY6JR42WQ; Metrizoate de methylglucamine; 1-Deoxy-1-(methylamino)-D-glucitol 3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoate

Molecular Formula

C19H28I3N3O9

Molecular Weight

823.2

Smiles

CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)N(C)C(=O)C)I.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

Appearance

Typically exists as solids at room temperature

Boiling Point

409.7℃

Relative Density

1.404 (Predicted)

General Description

Metrizoate meglumine is an ionic, high-osmolality, tri-iodinated contrast medium used for diagnostic imaging procedures. The drug was employed in angiography, urography, and computed tomography (CT) enhancement but has been largely replaced by non-ionic low-osmolality agents.

Mechanism of Action

Metrizoate contains three iodine atoms per molecule, which attenuate X-rays more effectively than soft tissue. Following intravascular injection, it rapidly distributes in the extracellular fluid and is excreted unchanged by the kidneys via glomerular filtration. The high osmolality of the solution (about 1500 mOsm/kg) causes osmotic diuresis and endothelium-derived vasodilation.

Application

Metrizoate meglumine was indicated for intravenous urography, peripheral arteriography, and contrast-enhanced CT scanning.

Does Metrizoate Meglumine require protection from light during long-term storage?

Yes, it is photosensitive. Light exposure can cause photodegradation and release of free iodine. Store in light-resistant containers, preferably amber glass.

What is the recommended storage temperature for Metrizoate Meglumine?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which accelerates decomposition and formation of free iodine.

Is Metrizoate Meglumine stable in solution for radiographic contrast use?

Formulated solutions are stable when stored at room temperature and protected from light. We provide stability data for various concentrations and pH ranges (optimal pH 6.5-7.5).

How is the free iodine content monitored during stability?

Free iodide is quantified using ion chromatography or a validated colorimetric method, ensuring it remains below pharmacopoeial limits for injectable contrast agents.