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Cat Number: API1223403584

LarotrectinibLOXO-101, ARRY-470

CAS Number

1223403-58-4

Description

Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase, demonstrating high selectivity exclusively for the TRK family of receptors (IC50s = 2-20 nM).

Molecular Formula

C21H22F2N6O2

Molecular Weight

428.44

Smiles

O[C@H]1CCN(C1)C(=O)NC1CNN2CCC(NC12)N1CCC[C@@H]1C1CC(F)CCC1F

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 4.6 mg/mL (10.74 mM)

Relative Density

1.55 (Predicted)

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