L-Tyr-NCA

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Cat Number

INT3415085

CAS Number

3415-08-5

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Product Detail Description Customer Q&A

CAS Number

3415-08-5

Storage

Store at -20℃

Synonyms

N-Carboxy-L-tyrosine anhydride;(4S)-4-[(4-Hydroxyphenyl)methyl]-2,5-oxazolidinedione;L-Tyrosine N-carboxyanhydride

Molecular Formula

C10H9NO4

Molecular Weight

207.18

Smiles

O1C(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O

Appearance

Light beige to pale orange solid

Relative Density

1.42

pKa

9.14

General Description

L-Tyr-NCA (L-Tyrosine N-carboxyanhydride) is a highly reactive cyclic derivative of tyrosine used for the rapid polymerization and synthesis of amino acid chains.

Mechanism of Action

It acts as a self-activating monomer. Upon initiation by a nucleophile, the NCA ring opens to release carbon dioxide and form a new peptide bond, allowing for the synthesis of high-molecular-weight polytyrosine or block copolymers without coupling reagents.

Application

It is extensively applied in the preparation of polypeptide-based biomaterials, drug delivery nanocarriers, and surface coatings for medical devices.