Iotrolan

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Cat Number

API79770244

CAS Number

79770-24-4

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Product Detail Description Customer Q&A

CAS Number

79770-24-4

Storage

2-8℃

Synonyms

5,5'-[(1,3-Dioxo-1,3-propanediyl)bis(methylimino)]bis[N,N'-bis[2,3-dihydroxy-1-(hydroxymethyl)propyl]-2,4,6-triiodo-1,3-benzenedicarboxamide];2,4,6-triiodo-5-[methyl-[Chemicalbook3-[methyl-[2,4,6-triiodo-3,5-bis(1,3,4-trihydroxybutan-2-ylcarbamoyl)phenyl]amino]-3-oxo-propanoyl]amino]-N1,N3-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicarboxamide

Molecular Formula

C37H48I6N6O18

Molecular Weight

1626.2

Smiles

CN(C1=C(C(=C(C(=C1I)C(=O)NC(CO)C(CO)O)I)C(=O)NC(CO)C(CO)O)I)C(=O)CC(=O)N(C)C2=C(C(=C(C(=C2I)C(=O)NC(CO)C(CO)O)I)C(=O)NC(CO)C(CO)O)I

Boiling Point

1390.4℃

Relative Density

2.3

pKa

5.5

General Description

Iotrolan is a non-ionic, dimeric iodinated contrast medium specifically designed for myelography and cisternography. Unlike conventional intravascular contrast agents, it is formulated for intrathecal use and is characterized by high hydrophilicity, low protein binding, and minimal neurotoxicity.

Mechanism of Action

Iotrolan provides radiographic contrast by X-ray attenuation through its iodine atoms. Its very low protein binding, high hydrophilicity, and pharmacokinetic inertness allow it to remain in cerebrospinal fluid for extended periods without significant neuronal uptake or metabolism.

Application

Used in diagnostic myelography and cisternography for imaging the spinal canal and subarachnoid space. Iotrolan is a non-ionic dimeric contrast agent specifically formulated for intrathecal use with high hydrophilicity, near-zero protein binding, and minimal neurotoxicity, providing superior safety for neuroradiological procedures.

What distinguishes Iotrolan from other contrast agents for spinal imaging?

Iotrolan is specifically designed for intrathecal use with extremely high water solubility, near-zero protein binding, and no intracellular penetration, making it uniquely safe for myelography.