Iothalamate Meglumine

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Cat Number

API0232096

CAS Number

13087-53-1

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Product Detail Description Customer Q&A

CAS Number

13087-53-1

EINECS

235-998-9

Storage

Store at room temperature

Synonyms

Iotalamate Meglumine; Cysto-conray II; Methylglucamine iotalamate; Methylglucamine iothalamate

Molecular Formula

C18H26I3N3O9

Molecular Weight

809.1

Smiles

CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)C(=O)NC)I.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

Appearance

Sterile aqueous solution

General Description

Iothalamate meglumine is an ionic, high‑osmolality, tri‑iodinated radiographic contrast medium formed by combining iothalamic acid with meglumine (N‑methylglucamine). Each molecule contains three iodine atoms for X‑ray attenuation and carries a net negative charge. The meglumine counterion improves water solubility and reduces the viscosity of the concentrated solution compared to the sodium salt.

Mechanism of Action

The three iodine atoms per molecule strongly absorb X‑rays, creating contrast between blood vessels, organs, and surrounding tissues. Following intravascular injection, iothalamate distributes in the extracellular fluid and is excreted unchanged by glomerular filtration without tubular reabsorption or metabolism. Its high osmolality (approximately 1500 mOsm/kg) induces osmotic diuresis and endothelium‑derived vasodilation, which are direct physicochemical effects.

Application

Iothalamate meglumine was historically used for intravenous urography, cerebral angiography, peripheral arteriography, and contrast‑enhanced computed tomography.

Does Iothalamate Meglumine require protection from light during storage?

Yes, it is photosensitive. Light exposure can cause photodegradation and release of free iodine. Store in light-resistant containers, preferably amber glass.

What is the recommended storage temperature for Iothalamate Meglumine?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which accelerates decomposition and free iodine formation.

Is Iothalamate Meglumine stable in solution for radiographic contrast use?

Formulated solutions are stable when stored at room temperature and protected from light.

How is the free iodine content monitored during stability?

Free iodide is quantified using ion chromatography or a validated colorimetric method, ensuring it remains below pharmacopoeial limits for injectable contrast agents.