Iofetamine Hydrochloride I-123

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Cat Number

API0231644

CAS Number

85068-76-4

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Product Detail Description Customer Q&A

CAS Number

85068-76-4

Storage

Store at 2-8℃

Synonyms

Iofetamine hydrochloride I 123; Spectamine; (sup 123)I-M123; UNII-R5O1XB5L3M; Iofetamine (123 i) hcl; R5O1XB5L3M; Iofetamine i 123 hydrochloride

Molecular Formula

C12H19ClIN

Molecular Weight

335.64

Smiles

CC(C)NC(C)CC1=CC=C(C=C1)[123I].Cl

General Description

Iofetamine hydrochloride I-123 (IMP) is a radiopharmaceutical used for single-photon emission computed tomography (SPECT) imaging of regional cerebral blood flow. It is a lipophilic amine that crosses the blood-brain barrier rapidly.

Mechanism of Action

After injection, iofetamine I-123 is taken up by the brain in proportion to regional blood flow, with distribution reflecting perfusion to cerebral tissues. It binds non-specifically to high-capacity, low-affinity binding sites on neurons. The iodine-123 isotope emits gamma radiation (159 keV), which is detected by a SPECT camera to generate 3D images of cerebral perfusion.

Application

Iofetamine I-123 was indicated for the evaluation of regional cerebral perfusion in patients with suspected stroke, transient ischemic attacks, dementia, and seizure focus localization. It is also used to assess brain death.

Does Iofetamine Hydrochloride I-123 require strict cold chain and shielding due to radioactivity?

Yes, as a radiopharmaceutical with I-123 (half-life ~13 hours), it must be stored at 2-8°C in lead-shielded containers with radiation monitoring.

What is the stability of Iofetamine Hydrochloride I-123 given its short half-life?

Radiochemical purity decreases over time due to radiolysis. We recommend use within 24 hours of calibration time. Stability data is provided with each batch.

Is Iofetamine Hydrochloride I-123 sensitive to light and heat during transport?

Yes, it is photosensitive and thermally labile. Shipments use temperature-controlled, light-protected, radiation-shielded containers with real-time tracking.

How is the radiochemical purity (free iodide and radiochemical impurities) monitored?

Radiochemical purity is measured using radio-TLC or radio-HPLC, ensuring free iodide and other impurities are below regulatory limits (typically <5%).