IL-6-2

Interleukin-6, IL-6, B-cell differentiation factor, B-cell stimulatory factor 2, BSF2; BSF-2, CDF, CTL differentiation factor, HSF, IFNB2, IFN-beta-2, Interferon beta-2, interleukin BSF-2, MGI-2A.

Interleukin 6 (IL-6), which was originally identified as a B-cell differentiation factor, is now known to be a multifunctional cytokine that regulates the immune response, hematopoiesis, the acute phase response, and inflammation. IL-6 is a pleiotropic, alpha -helical, 22-28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. Mature human IL-6 is 183 amino acids (aa) in length and shares 39% aa sequence identity with mouse and rat IL-6. It also induces myeloma and plasmacytoma growth. And it is a pleiotropic cytokine that not only affects the immune system, but also acts in other biological systems and many physiological events in various organs. In a target cell, IL-6 can simultaneously generate functionally distinct or sometimes contradictory signals through its receptor complex, IL-6Ralpha and gp130.

Approximately 21.7 kDa.

Sterile Filtered White lyophilized (freeze-dried) powder.

> 97% by SDS-PAGE and HPLC analyses.