Hydrocortisone Valerate

Inquiry

Cat Number

API57524897

CAS Number

57524-89-7

If you have any other questions, please contact our experts.

Product Detail Description Advanced Innovations Customer Q&A

CAS Number

57524-89-7

EINECS

260-786-8

Storage

2-8℃

Synonyms

11β,17,21-trihydroxypregn-4-ene-3,20-dione 17-valerate

Molecular Formula

C26H38O6

Molecular Weight

446.6

Smiles

CCCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)C(=O)CO

Appearance

White to off-white solid

Melting Point

217-220℃

Boiling Point

595.1℃

Relative Density

1.2

General Description

Hydrocortisone Valerate is the 17-valerate ester of hydrocortisone (cortisol), a naturally occurring glucocorticoid. The esterification at C-17 with a pentanoic acid group enhances lipophilicity compared to unesterified hydrocortisone, improving tissue penetration and prolonging anti-inflammatory activity.

Mechanism of Action

Hydrocortisone Valerate binds to intracellular glucocorticoid receptors; the receptor-steroid complex modulates transcription by interacting with glucocorticoid response elements, suppressing inflammatory gene expression and reducing production of prostaglandins, leukotrienes, and pro-inflammatory cytokines.

Application

Indicated for the treatment of inflammatory skin conditions including eczema, atopic dermatitis, and contact dermatitis. Hydrocortisone Valerate is a naturally occurring glucocorticoid with a 17-valerate ester that enhances lipophilicity, providing improved dermal penetration and prolonged topical anti-inflammatory activity.

Hydrocortisone loaded poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles were prepared by emulsification-solvent evaporation for topical ophthalmic administration. The nanoparticles exhibited a mean size of 237.3 nm with encapsulation efficiency of 1 to 2.5 percent. In vitro drug release followed the Higuchi kinetic model. Confocal microscopy confirmed efficient corneal penetration of PHBV nanoparticles. Toxicity assessments using bovine keratocyte viability assays, HET-CAM and BCOP tests demonstrated that the formulation was non-cytotoxic and non-irritating, with no alteration of corneal transparency or permeability.

Fig. 2 SEM micrographs. (A) PHBV-NPs, (B) Encapsulate Hydrocortisone (HC)-PHBV-NPs. (Alvarez-Alvarez L.; et al. 2019)

References

Alvarez-Alvarez L, et al. Hydrocortisone loaded poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles for topical ophthalmic administration: Preparation, characterization and evaluation of ophthalmic toxicity. International journal of pharmaceutics, 2019, 568: 118519.

How does Hydrocortisone Valerate differ from unesterified hydrocortisone?

The 17-valerate esterification significantly increases lipophilicity, improving corneal layer penetration and providing more potent and sustained anti-inflammatory activity.

What storage conditions are required?

Should be stored at 2-8℃ in a tightly sealed container, protected from light and moisture.

What purity grade is available?

Supplied as a high-purity grade suitable for R&D and pharmaceutical manufacturing.

Can packaging be customized?

Both are customizable upon request to meet specific R&D and production needs.