Guanethidine Monosulfate

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Cat Number

API0232247

CAS Number

645-43-2

For research use only. We do not supply to patients.

For pharmaceutical-grade products or other inquiries, please contact our experts.

Product Detail Description Customer Q&A

CAS Number

645-43-2

EINECS

211-442-0

Storage

Store at room temperature

Synonyms

guanethidine monosulphate; 5UBY8Y002G; 2-(Octahydro-1-azocinyl)ethyl guanidine sulphate; Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate (1:1)

Molecular Formula

C10H24N4O4S

Molecular Weight

296.39

Smiles

C1CCCN(CCC1)CCN=C(N)N.OS(=O)(=O)O

Appearance

White to light yellow powder to crystal

Melting Point

251-256°C (with decomposition)

General Description

Guanethidine monosulfate is a synthetic guanidine derivative with a cyclohexyl group and an ethylamine side chain, acting as an adrenergic neuron blocker. Its chemical structure is [2-(1-azocanyl)ethyl]guanidine sulfate. Guanethidine is a white to off-white powder, soluble in water. The molecule is a potent inhibitor of norepinephrine release from sympathetic nerve terminals.

Mechanism of Action

Guanethidine acts by blocking the release of norepinephrine from the presynaptic nerve terminals of the sympathetic nervous system. It is taken up into the nerve terminals by the norepinephrine transporter (NET) and accumulates in the vesicles, displacing norepinephrine and inhibiting its release. This leads to a decrease in peripheral vascular resistance and blood pressure.

Application

Guanethidine is indicated for the treatment of severe hypertension in patients who are refractory to other antihypertensive agents. It is also used for the management of hypertension in patients with renal failure and for the treatment of certain types of glaucoma (as an eye drop).

Does Guanethidine Monosulfate require protection from light and moisture during storage?

Yes, it is sensitive to both light and moisture. Light causes photodegradation and moisture promotes hydrolysis of the guanidine group. Store in light-resistant, tightly sealed containers with desiccant.

What is the recommended storage temperature for Guanethidine Monosulfate?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which can accelerate decomposition of the sulfate salt.

Is Guanethidine Monosulfate stable in solution for parenteral use?

Aqueous solutions are stable when protected from light and stored at room temperature.

How is the impurity guanethidine N-oxide (an oxidative degradation product) monitored?

This degradation product is quantified using a stability-indicating HPLC method, ensuring it remains within pharmacopoeial limits.

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