Glutethimide

Inquiry

Cat Number

API0231568

CAS Number

77-21-4

If you have any other questions, please contact our experts.

Product Detail Description Customer Q&A

CAS Number

77-21-4

EINECS

201-012-0

Storage

Store at room temperature

Synonyms

Doriden; Sarodormin; Elrodorm; Noxyron; Glutethimid; Gluthetimide; Glutetimid; Rigenox; Glutathimid; Glutetimide; Glimid; 2-Ethyl-2-phenylglutarimide

Molecular Formula

C13H15NO2

Molecular Weight

217.26

Smiles

CCC1(CCC(=O)NC1=O)C2=CC=CC=C2

Appearance

White to off-white crystalline powder

Melting Point

84℃

Boiling Point

357.82℃

Relative Density

1.096

General Description

Glutethimide is a hypnotic and sedative that was introduced in 1954 as a potential non-barbiturate alternative for the treatment of insomnia.

Mechanism of Action

The exact mechanism of action has not been fully elucidated, but it is believed to function as a GABA agonist, which helps induce sedation. By potentiating GABAergic transmission in the central nervous system, it produces central nervous system depression. Additionally, it induces CYP2D6, which can alter the metabolism of co-administered drugs that are substrates of this enzyme.

Application

Glutethimide was originally indicated for the treatment of insomnia, but its use has now been largely superseded by other drugs with better safety profiles. Its historical use has also included the treatment of essential tremor and intention tremor, with evidence suggesting efficacy.

Does Glutethimide require protection from light during long-term storage?

Yes, it is photosensitive. Prolonged UV exposure can cause photodegradation and discoloration. Store in light-resistant, tightly sealed containers.

What is the recommended storage temperature for Glutethimide?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which can cause softening or melting of the crystalline powder.

Is Glutethimide susceptible to hydrolysis in the presence of moisture?

It is relatively stable, but under high humidity and elevated temperatures, the glutarimide ring may hydrolyze. Store with desiccant for long-term stability.

How is the impurity 2-ethyl-2-phenylglutarimide monitored?

This related substance is quantified using a stability-indicating HPLC method, ensuring it remains below USP limits throughout the product's shelf life.