Synonyms
Gemcitabine 5'-elaidate, Gemcitabine (elaidate), CO-101, CP-4126
Description
Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase.
Molecular Formula
C27H43F2N3O5
Storage
Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.
Solubility Information
DMSO: 26 mg/mL (49.28 mM)
Relative Density
1.20 (Predicted)