Cat Number: 91105ES

G-CSF-4

Source

E.coli

Synonyms

Granulocyte Colony-Stimulating Factor, CSF-3, MGI-1G, GM-CSF beta, pluripoietin

Description

G-CSF is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It is produced in response to specific stimulation by a variety of cells, including macrophages, fibroblasts, endothelial cells and bone marrow stroma. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. Human and murine G-CSF are cross-species reactive.

Molecular Weight

Approximately 18.9 kDa

AA sequence

TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA LQEKLCATYK LCHPEELVLL RHSLGIPWAP LSSCPSQALQ LTGCLSQLHS SLFLYQGLLQ ALEGISPELS PTLDTLQLDI ADFATTIWQQ MEDLGMAPAL QPTQGAMPAF TSAFQRRAGG VLVASHLQRF LELAYRVLRH LAQS

Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Purity

> 98% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine NFS-60 cells is less than 0.05 ng/mL, corresponding to a specific activity of > 2.0 × 107 IU/mg.

Endotoxin

< 0.1 EU per 1μg of the protein

Formulation

Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.

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Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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