Fosaprepitant dimeglumine

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Cat Number

API265121048

CAS Number

265121-04-8

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Product Detail

CAS Number

265121-04-8

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Description

Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, a water-soluble, N-phosphorylated prodrug of aprepitant with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent selectively binds to human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS), inhibiting receptor binding of endogenous substance P and preventing substance P-induced emesis.

Molecular Formula

C37H56F7N6O16P

Molecular Weight

1004.83

Smiles

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C[C@@H](O[C@H]1OCCN(CC2NN(C(=O)[NH]2)P(O)(O)=O)[C@H]1C1CCC(F)CC1)C1CC(CC(C1)C(F)(F)F)C(F)(F)F

Purity

0.9875

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