Fomepizole

Inquiry

Cat Number

API0232233

CAS Number

7554-65-6

For research use only. We do not supply to patients.

For pharmaceutical-grade products or other inquiries, please contact our experts.

Product Detail Description Customer Q&A

CAS Number

7554-65-6

EINECS

231-445-0

Storage

Store at room temperature

Synonyms

1H-Pyrazole, 4-methyl-; Fomepizol; 4-Methylpyrazol; Fomepizolum; 83LCM6L2BY; DTXSID3040649; 4 Methylpyrazole

Molecular Formula

C4H6N2

Molecular Weight

82.1

Smiles

CC1=CNN=C1

Appearance

Off-white to light yellow powder (<13°C), liquid (>13°C)

Melting Point

13°C

Boiling Point

243.6±0.0°C at 760 mmHg

Relative Density

1.1±0.1

General Description

Fomepizole is a small molecule with a pyrazole ring and a methyl group, chemically known as 4-methylpyrazole. Its structure is a five-membered ring with two nitrogen atoms and a methyl substituent. Fomepizole is a clear, colorless liquid that is freely soluble in water. It is a potent inhibitor of the enzyme alcohol dehydrogenase (ADH).

Mechanism of Action

Fomepizole acts as a competitive inhibitor of alcohol dehydrogenase, the enzyme responsible for the first step in the metabolism of methanol and ethylene glycol. By blocking the conversion of methanol to formaldehyde and formic acid, and ethylene glycol to glycolic acid and oxalic acid, it prevents the accumulation of toxic metabolites. The drug has a higher affinity for ADH than ethanol, making it a more effective inhibitor.

Application

Fomepizole is indicated as an antidote for the treatment of methanol and ethylene glycol poisoning. It is used in patients with confirmed or suspected toxic alcohol ingestion to prevent the formation of toxic metabolites and to reduce the risk of metabolic acidosis, renal failure, and blindness. The drug is also used for the treatment of adverse reactions to disulfiram.

Does Fomepizole require protection from light and moisture during storage?

It is moderately sensitive to light and moisture. Store in light-resistant, tightly sealed containers with desiccant at controlled room temperature (15-25°C).

Is Fomepizole stable in solution for injectable use?

Aqueous solutions are stable when protected from light and stored at room temperature.

What is the stability of Fomepizole after reconstitution for intravenous administration?

Reconstituted solutions are stable for up to 24 hours at room temperature when protected from light.

How is the impurity 4-carboxypyrazole (an oxidation product) monitored?

This degradation product is specifically quantified using a stability-indicating HPLC method, ensuring it remains within pharmacopoeial limits.

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

INFORMATION

Member of

CERTIFICATION

USA

Tel:
Email:
Address:

Denmark

Tel:
Email:
Address:

WhatsAPP (Sales #1)

WhatsAPP (Sales #2)

WhatsAPP (Sales #3)

All our products are chemicals for research purposes only. We do not supply for human or veterinary applications.