FMOC-THR(TBU)-OL

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Cat Number

INT189337288

CAS Number

189337-28-8

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Product Detail Description Customer Q&A

CAS Number

189337-28-8

Storage

2-8℃

Synonyms

N-FMOC-L-THR(TBU)-OL;N-FMOC-L-THR(TBU)-OL-N-FMOC-(2R,3R)-2-AMINO-3-T-BUTOXY-1-BUTANOL;N-FMOC-(2R,3R)-2-AMINO-3-T-BUTOXY-1-BUTANOL;N-ALPHA-FMOC-O-T-BUTYL-L-THREONINOL

Molecular Formula

C23H29NO4

Molecular Weight

383.48

Smiles

C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)N[C@H](CO)[C@H](OC(C)(C)C)C

Appearance

White to off-white solid

Boiling Point

576.5℃

Relative Density

1.14

pKa

General Description

FMOC-THR(TBU)-OL is a reduced alcohol derivative of Fmoc-L-threonine with the side-chain hydroxyl protected as a tert-butyl ether. It combines Fmoc chemistry with the structural versatility of an amino alcohol.

Mechanism of Action

It serves as a chiral building block where the terminal alcohol can be used for further derivatization, such as phosphorylation or etherification, while the Fmoc and tBu groups provide orthogonal protection for the amine and side chain.

Application

It is used in the synthesis of specialized glycopeptide mimetics, chiral catalysts, and as an intermediate for producing complex threonine-derived pharmaceutical scaffolds.