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Fmoc-N-methyl-L-leucine

Fmoc-N-methyl-L-leucine

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Cat Number
INT103478622
CAS Number
103478-62-2

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CAS Number
103478-62-2
Storage
Store at room temperature
Synonyms
N-ALPHA-FMOC-N-ALPHA-METHYL-L-LEUCINE;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-L-LEUCINE
Molecular Formula
C22H25NO4
Molecular Weight
367.44
Smiles
C(O)(=O)[C@H](CC(C)C)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C
Appearance
White powder
Melting Point
113-116℃
Boiling Point
537.3℃
Relative Density
1.19
pKa
3.93
General Description
Fmoc-N-methyl-L-leucine is a protected amino acid where the isobutyl side chain of leucine is paired with an N-methylated backbone nitrogen, protected by the Fmoc group.
Mechanism of Action
It serves as a building block for creating constrained peptide helices or turns. The bulky side chain and N-methyl group work together to restrict the conformational space of the peptide chain.
Application
It is extensively applied in the development of antimicrobial peptides and as a component in the total synthesis of bioactive natural products.

How should Fmoc-N-methyl-L-leucine be stored?

It should be stored in a cool, dry place in a tightly sealed container.

Is Fmoc-N-methyl-L-leucine stable at room temperature?

It is recommended to keep it under refrigeration for long-term stability.

Does Fmoc-N-methyl-L-leucine meet industry standards?

Yes, its production is compliant with international industry standards.

Are COAs provided for Fmoc-N-methyl-L-leucine?

Yes, every batch of it includes a batch-specific COA.

What is the role of Fmoc-N-methyl-L-leucine?

It acts as a key intermediate for synthesizing N-methylated pharmaceutical peptides.
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