Fmoc-N-methyl-L-leucine

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Cat Number

INT103478622

CAS Number

103478-62-2

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Product Detail Description Customer Q&A

CAS Number

103478-62-2

Storage

Store at room temperature

Synonyms

N-ALPHA-FMOC-N-ALPHA-METHYL-L-LEUCINE;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-L-LEUCINE

Molecular Formula

C22H25NO4

Molecular Weight

367.44

Smiles

C(O)(=O)[C@H](CC(C)C)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C

Appearance

White powder

Melting Point

113-116℃

Boiling Point

537.3℃

Relative Density

1.19

pKa

3.93

General Description

Fmoc-N-methyl-L-leucine is a protected amino acid where the isobutyl side chain of leucine is paired with an N-methylated backbone nitrogen, protected by the Fmoc group.

Mechanism of Action

It serves as a building block for creating constrained peptide helices or turns. The bulky side chain and N-methyl group work together to restrict the conformational space of the peptide chain.

Application

It is extensively applied in the development of antimicrobial peptides and as a component in the total synthesis of bioactive natural products.