Fmoc-N-Me-Tyr(tBu)-OH

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Cat Number

INT133373247

CAS Number

133373-24-7

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Product Detail Description Customer Q&A

CAS Number

133373-24-7

Storage

2-8℃

Synonyms

N-FMoc-N-Methyl-O-tert-butyl-L-tyrosine;fMoc-N-Me-tyr(tbu)-oh;FMOC-L-METYR(TBU)-OH

Molecular Formula

C29H31NO5

Molecular Weight

473.56

Smiles

C(O)(=O)[C@H](CC1=CC=C(OC(C)(C)C)C=C1)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C

Appearance

White to off-white solid

Melting Point

186-191℃

Boiling Point

638.9℃

Relative Density

1.21

pKa

2.98

General Description

Fmoc-N-Me-Tyr(tBu)-OH is a triply protected tyrosine derivative with an Fmoc group on the N-methylated amine and a tert-butyl ether protecting the phenolic side chain.

Mechanism of Action

It serves as an orthogonal building block for SPPS. The N-methyl group modulates the peptide backbone geometry, while the tBu side-chain protection is easily removed by TFA, allowing for precise control during synthesis.

Application

It is widely applied in the construction of N-methylated therapeutic peptides and in SAR studies to improve the pharmacokinetic profiles of lead compounds.