Fmoc-N-Me-Tyr(tBu)-OH

Fmoc-N-Me-Tyr(tBu)-OH

Cat Number
INT133373247
CAS Number
133373-24-7

If you have any other questions, please contact our experts.

CAS Number
133373-24-7
Storage
2-8℃
Synonyms
N-FMoc-N-Methyl-O-tert-butyl-L-tyrosine;fMoc-N-Me-tyr(tbu)-oh;FMOC-L-METYR(TBU)-OH
Molecular Formula
C29H31NO5
Molecular Weight
473.56
Smiles
C(O)(=O)[C@H](CC1=CC=C(OC(C)(C)C)C=C1)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C
Appearance
White to off-white solid
Melting Point
186-191℃
Boiling Point
638.9℃
Relative Density
1.21
pKa
2.98
General Description
Fmoc-N-Me-Tyr(tBu)-OH is a triply protected tyrosine derivative with an Fmoc group on the N-methylated amine and a tert-butyl ether protecting the phenolic side chain.
Mechanism of Action
It serves as an orthogonal building block for SPPS. The N-methyl group modulates the peptide backbone geometry, while the tBu side-chain protection is easily removed by TFA, allowing for precise control during synthesis.
Application
It is widely applied in the construction of N-methylated therapeutic peptides and in SAR studies to improve the pharmacokinetic profiles of lead compounds.

How should Fmoc-N-Me-Tyr(tBu)-OH be stored?

It should be kept at 2-8℃ in a desiccated environment.

Is Fmoc-N-Me-Tyr(tBu)-OH soluble in SPPS solvents?

Yes, it is highly soluble in DMF and NMP.

Does Fmoc-N-Me-Tyr(tBu)-OH meet industry standards?

Yes, its manufacturing is compliant with international industry standards.

Are COAs provided for Fmoc-N-Me-Tyr(tBu)-OH?

Yes, every batch of it includes a Certificate of Analysis.

Can Fmoc-N-Me-Tyr(tBu)-OH be shipped globally?

Yes, it is available for international logistics via secure packaging.
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