FMOC-LHOMOPHENYLALANINE

Inquiry

Cat Number

INT132684594

CAS Number

132684-59-4

If you have any other questions, please contact our experts.

Product Detail Description Customer Q&A

CAS Number

132684-59-4

Storage

2-8℃

Synonyms

(S)-2-(Fmoc-amino)-4-phenylbutyric acid, Fmoc-L-homophenylalanine;Fmoc-L-Beta-homo-Phe;FMOC-SS-HOMO-PHE-OH

Molecular Formula

C25H23NO4

Molecular Weight

401.45

Smiles

C1=CC=C(C=C1)CC[C@@H](C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Appearance

White to off-white solid

Melting Point

141.0 to 145.0℃

Boiling Point

628.3℃

Relative Density

1.25

pKa

3.84

General Description

FMOC-LHOMOPHENYLALANINE is the Fmoc-protected version of L-homophenylalanine, an amino acid where an extra methylene group is inserted between the alpha-carbon and the phenyl ring.

Mechanism of Action

It acts as an elongated hydrophobic building block. The extra carbon atom provides increased flexibility and alters the distance between the peptide backbone and the aromatic side chain, which can lead to unique molecular recognition profiles.

Application

It is primarily used in the development of angiotensin-converting enzyme (ACE) inhibitors and as a structural tool in the synthesis of diverse pharmaceutical intermediates.