Fmoc-His(Trt)-Aib-OH

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Cat Number

INT1446013133

CAS Number

1446013-13-3

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Product Detail Description Customer Q&A

CAS Number

1446013-13-3

Synonyms

(S)-2-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoic acid;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine-2-methylalanine

Molecular Formula

C44H40N4O5

Molecular Weight

704.81

Smiles

C(O)(=O)[C@](C)(C)NC(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

Boiling Point

921.4℃

Relative Density

1.23

pKa

3.4

General Description

Fmoc-His(Trt)-Aib-OH is a protected dipeptide featuring Fmoc-protected histidine with a trityl (Trt) side-chain group, coupled to the non-natural amino acid alpha-aminoisobutyric acid (Aib).

Mechanism of Action

It serves as a conformational constraint fragment. The Aib residue induces a helical structure in the peptide backbone, while the His(Trt) group ensures compatible protection for standard Fmoc-based SPPS.

Application

It is a critical component for the synthesis of GLP-1 receptor agonists and other therapeutic peptides where a stable alpha-helical conformation is required.