Fmoc-Gly-Arg(Pbf)-OH

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Cat Number

INT1048377781

CAS Number

1048377-78-1

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Product Detail Description Customer Q&A

CAS Number

1048377-78-1

Synonyms

(2S)-2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-5-[[2-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonyl]hydrazinyl]methylideneamino]pentanoic acid

Molecular Formula

C36H43N5O8S

Molecular Weight

705.82

Smiles

C(O)(=O)[C@H](CCCNC=NNS(C1=C(C)C(C)=C2OC(C)(C)CC2=C1C)(=O)=O)NC(=O)CNC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

Relative Density

1.39

pKa

3.41

General Description

Fmoc-Gly-Arg(Pbf)-OH is a protected dipeptide building block featuring an Fmoc group on the glycine and a Pbf (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl) group on the arginine side chain.

Mechanism of Action

It serves as a pre-formed fragment for SPPS. The Pbf group is the most effective protector for the guanidino group of arginine, offering high stability during synthesis and rapid removal during TFA cleavage.

Application

It is utilized to streamline the synthesis of arginine-rich peptides, such as cell-penetrating peptides (CPPs) and RGD-containing therapeutic leads.