Fmoc-D-Tyr(4-Et)-OH

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Cat Number

INT162502650

CAS Number

162502-65-0

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Product Detail Description Customer Q&A

CAS Number

162502-65-0

Storage

2-8℃

Synonyms

FMOC-O-ETHYL-D-TYROSINE;FMOC-P-ETHOXY-D-PHE-OH;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-ETHYL-D-TYROSINE;N-ALPHA-FMOC-O-ETHYL-D-TYROSINE

Molecular Formula

C26H25NO5

Molecular Weight

431.48

Smiles

C(O)(=O)[C@@H](CC1=CC=C(OCC)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

Appearance

White to off-white solid

Boiling Point

654.3℃

Relative Density

1.25

pKa

2.96

General Description

Fmoc-D-Tyr(4-Et)-OH is an Fmoc-protected D-tyrosine derivative featuring an ethyl ether on the phenolic hydroxyl. As a D-enantiomer, it is used to incorporate non-natural chirality into peptide frameworks.

Mechanism of Action

It functions as a chiral building block for Fmoc-based SPPS. The D-configuration and the O-ethyl modification together alter the peptide's secondary structure and its metabolic profile, effectively resisting enzymatic degradation by typical L-proteases.

Application

It is utilized in the design of peptidomimetics, particularly for developing stable analogs of opioid peptides and other receptor ligands requiring enhanced pharmacokinetics.