Fmoc-D-Me-Ala-OH

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Cat Number

INT138774922

CAS Number

138774-92-2

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Product Detail Description Customer Q&A

CAS Number

138774-92-2

Storage

2-8℃

Synonyms

FMOC-N-ALPHA-METHYL-D-ALANINE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-D-ALANINE

Molecular Formula

C19H19NO4

Molecular Weight

325.36

Smiles

C(O)(=O)[C@@H](C)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C

Appearance

White to off-white solid

Boiling Point

514.9℃

Relative Density

1.26

pKa

3.92

General Description

Fmoc-D-Me-Ala-OH is the Fmoc-protected version of N-methyl-D-alanine, providing a small but structurally significant chiral building block for asymmetric synthesis.

Mechanism of Action

It functions as a D-configured N-methylated unit. By incorporating a D-amino acid with N-methylation, researchers can create "retro-inverso" peptide analogs that are almost entirely resistant to natural proteases while maintaining specific spatial orientations.

Application

It is widely used in the development of therapeutic peptide leads where metabolic stability and a specific D-conformation are required for target binding.