FMOC-ASP(OCHEX)-OH

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Cat Number

INT130304802

CAS Number

130304-80-2

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Product Detail Description Customer Q&A

CAS Number

130304-80-2

Storage

2-8℃

Synonyms

FMOC-L-ASPARATIC ACID-BETA-CYCLOHEXYL ESTER;FMOC-L-ASPARTIC ACID BETA-CYCLOHEXYL ESTER

Molecular Formula

C25H27NO6

Molecular Weight

437.48

Smiles

C1CCC(CC1)OC(=O)C[C@@H](C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Appearance

White to off-white solid

Boiling Point

667.8℃

Relative Density

1.31

pKa

3.55

General Description

FMOC-ASP(OCHEX)-OH is a side-chain protected aspartic acid derivative where the carboxyl group is masked as a cyclohexyl ester. This specific protection reduces side reactions such as aspartimide formation.

Mechanism of Action

It acts as a sterically hindered building block. The cyclohexyl ester (OChx) provides better stability compared to simpler esters, minimizing unwanted cyclization during chain elongation in solid-phase synthesis.

Application

It is a premium choice for the synthesis of complex peptides containing aspartic acid sequences where high purity and minimal by-products are critical.