FMOC-ALLO-THR-OH

Inquiry

Cat Number

INT146306754

CAS Number

146306-75-4

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Product Detail Description Customer Q&A

CAS Number

146306-75-4

Storage

2-8℃

Synonyms

FMOC-L-ALLO-THREONINE;FMOC-THR(ALLO)-OH;N-[(9-Fluorenylmethoxy)carbonyl]-L-allo-threonine;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-ALLO-L-THREONINE

Molecular Formula

C19H19NO5

Molecular Weight

341.36

Smiles

C[C@@H]([C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)O

Appearance

White to off-white solid

Boiling Point

596.5℃

Relative Density

1.33

pKa

3.49

General Description

FMOC-ALLO-THR-OH is the Fmoc-protected form of L-allo-threonine, a diastereomer of the natural amino acid L-threonine. It features a different configuration at the beta-carbon, providing unique spatial properties.

Mechanism of Action

It serves as a non-natural building block in peptide chemistry. By incorporating the allo-configuration, it allows researchers to probe the structural requirements of enzyme binding sites and modulate the folding patterns of synthetic proteins.

Application

It is primarily used in the synthesis of natural product analogs, cyclic peptides, and as a tool in structural biology to study protein-protein interactions.