Exendin-4

Exenatide

Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.

Approximately 4.2 kDa, a single non-glycosylated polypeptide chain containing 39 amino acids.

Sterile Filtered White lyophilized (freeze-dried) powder.

> 96 % by SDS-PAGE and HPLC analyses.