Ethyl 4,6-dichloronicotinate

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Cat Number

INT40296466

CAS Number

40296-46-6

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Product Detail Description Customer Q&A

CAS Number

40296-46-6

Storage

Store at room temperature

Synonyms

4,6-Dichloronicotinic acid ethyl ester

Molecular Formula

C8H7Cl2NO2

Molecular Weight

220.05

Smiles

C1=NC(Cl)=CC(Cl)=C1C(OCC)=O

Appearance

Yellow liquid

Boiling Point

85℃

Relative Density

1.367

General Description

Ethyl 4,6-dichloronicotinate is an electron-deficient chlorinated pyridine ester. The presence of two chlorine atoms and an ethyl ester group on the pyridine ring makes it a highly reactive and versatile starting material for the synthesis of multi-substituted nicotinic acid derivatives.

Mechanism of Action

It provides a pyridine ring with two distinct electrophilic sites. The chlorine atoms at the C4 and C6 positions allow for selective nucleophilic substitution or metal-catalyzed coupling reactions, enabling the precise introduction of diverse functional groups onto the nicotinic acid scaffold.

Application

It is widely employed in pharmaceutical research for the synthesis of inflammatory inhibitors, specialized ligands, and other therapeutic agents requiring a substituted pyridine core.