Epinephrine Bitartrate

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Cat Number

API69815492

CAS Number

51-43-2

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Product Detail Description Customer Q&A

CAS Number

51-43-2

EINECS

625-097-2

Storage

Store at 2-8℃

Synonyms

D02149;Adrenalinium;ADRENAL, RAT;Adrenalin tartras;Adrenaline tatrate;Medihaler-epi (tn);adrenalinetartrate;Asmatane mist (tn);epinephrinetartrate;adrenalinbitartrate

Molecular Formula

C13H19NO9

Molecular Weight

333.29

Smiles

CNC[C@@H](C1=CC(=C(C=C1)O)O)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O

Appearance

White solid

Melting Point

>155°C (dec.)

Standard

GMP;FDA;DMF;COS

General Description

Epinephrine bitartrate is the bitartrate salt form of epinephrine, a direct-acting sympathomimetic amine and neurohormone produced by the adrenal medulla. Chemically, it is a salt formed from epinephrine and tartaric acid, and this salt formulation enhances the water solubility and stability of the epinephrine molecule for pharmaceutical preparations.

Mechanism of Action

The pharmacological effects of epinephrine bitartrate are mediated through its direct, non-selective agonism of adrenergic receptors throughout the sympathetic nervous system. The specific physiological response depends on the dose, route of administration, and the predominant receptor subtype in the target tissue.

Application

Epinephrine bitartrate is utilized across several specialties for its vasoconstrictive, bronchodilatory, and cardiac-stimulating properties, primarily as a component of combination products. The most common use of epinephrine bitartrate is as a vasoconstrictor added to local anesthetic solutions, such as bupivacaine or articaine.

How can I tell if Epinephrine Bitartrate has degraded due to improper storage?

A visual indicator of degradation is a distinct pink or brown coloration. We recommend immediate HPLC analysis if any color change is observed, as this indicates the formation of adrenochrome.

Does Epinephrine Bitatrate require an inert atmosphere (like nitrogen) for long-term storage?

For extended shelf life, we recommend storing unopened containers under a nitrogen blanket. Our bulk packaging can be purged with nitrogen upon request to prevent oxidation.

What is the particle size distribution for micronized Epinephrine Bitartrate?

For inhalation or suspension formulations, we offer micronized grades.

How should I dispose of expired or off-spec Epinephrine Bitartrate?

Expired Epinephrine Bitartrate should be treated as hazardous pharmaceutical waste. We recommend incineration at a licensed facility, following all local environmental regulations.