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Entrectinib

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Cat Number

API1108743607

CAS Number

1108743-60-7

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Product Detail

CAS Number

1108743-60-7

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Description

Entrectinib (RXDX-101) is a Trk, ROS1, and ALK inhibitor that inhibits TrkA, TrkB, TrkC, ROS1, and ALK (IC50=1/3/5/12/7 nM) with oral activity and blood-brain-barrier penetration. Entrectinib exhibits both antitumor and CNS activity.

Molecular Formula

C31H34F2N6O2

Molecular Weight

560.64

Smiles

N(C(=O)C1=C(NC2CCOCC2)C=C(C=C1)N3CCN(C)CC3)C=4C=5C(NN4)=CC=C(CC6=CC(F)=CC(F)=C6)C5

Relative Density

1.340 (Predicted)

Purity

0.9961

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