Diflorasone Diacetate

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Cat Number

API33564317

CAS Number

33564-31-7

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Product Detail Description Customer Q&A

CAS Number

33564-31-7

EINECS

251-575-1

Storage

2-8℃

Synonyms

6a,9-difluoro-11b,17,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17,21-diacetate

Molecular Formula

C26H32F2O7

Molecular Weight

494.5

Smiles

C[C@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)OC(=O)C)C)O)F)C)F

Appearance

White to off-white solid

Melting Point

221-223℃

Boiling Point

235℃

Relative Density

1.2

pKa

12.6

General Description

Diflorasone Diacetate is the 17,21-diacetate ester of diflorasone, a synthetic halogenated corticosteroid. It is classified as a very high potency glucocorticoid due to the combination of difluoro substitution at C-6 and C-9 and the diacetate esterification, which enhance receptor binding affinity and skin penetration.

Mechanism of Action

Diflorasone Diacetate binds to intracellular glucocorticoid receptors and the resulting complex modulates transcription factor activity (AP-1, NF-κB) to suppress inflammatory gene expression. This reduces production of pro-inflammatory mediators including prostaglandins, leukotrienes, and cytokines in target tissues.

Application

Indicated for the treatment of inflammatory and pruritic dermatoses requiring very high potency corticosteroid therapy. Diflorasone Diacetate is classified as a Class I (super-high potency) topical corticosteroid with difluoro substitution and diacetate esterification that maximize receptor binding and skin penetration.

What makes Diflorasone Diacetate a super-high potency corticosteroid?

Dual fluorine substitution at C-6 and C-9 combined with 17,21-diacetate esterification maximizes glucocorticoid receptor binding affinity and enhances lipophilicity for improved tissue penetration.

What storage conditions are required?

Should be stored at 2-8℃ in a tightly sealed container, protected from light and moisture.

What purity grade is available?

Supplied as a high-purity grade suitable for R&D and pharmaceutical manufacturing.

Can packaging be customized?

Both packaging formats and order quantities are customizable upon request for R&D and production needs.