Diatrizoate Sodium

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Cat Number

API737315

CAS Number

737-31-5

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CAS Number

737-31-5

EINECS

212-004-1

Storage

Room temperature

Synonyms

Sodium amidotrizoate

Molecular Formula

C11H8I3N2NaO4

Molecular Weight

635.89

Smiles

CC(=O)NC1=C(C(=C(C(=C1I)C(=O)[O-])I)NC(=O)C)I.[Na+]

Appearance

White to off-white powder

Melting Point

261-262℃

General Description

Diatrizoate Sodium is the sodium salt of diatrizoic acid (3,5-diacetamido-2,4,6-triiodobenzoic acid), a conventional ionic monomeric iodinated contrast medium. It is one of the earliest developed water-soluble iodinated contrast agents and contains three iodine atoms per molecule.

Mechanism of Action

Diatrizoate Sodium provides radiographic contrast through X-ray attenuation by its three iodine atoms per molecule. As an ionic monomer, it dissociates into two particles per molecule in solution, resulting in higher osmolality compared to non-ionic contrast agents at equivalent iodine concentrations.

Application

Used in diagnostic imaging for intravenous urography, angiography, and computed tomography (CT). Diatrizoate Sodium is one of the earliest developed ionic iodinated contrast agents, providing reliable radiographic density for a wide range of diagnostic imaging procedures.

Diatrizoic acid nanoparticle agglomerates were fabricated as an inhalable dry powder lung contrast agent using a precipitation method. The nanoparticle suspensions achieved a particle size of approximately 136 nm. These nanoparticles were assembled into microparticles suitable for dry powder insufflation to enable deposition in the lung periphery. Characterization studies confirmed the formation of uniform nanoparticle agglomerates. In vivo safety evaluation in rats demonstrated no acute alveolar tissue damage two hours after dry powder insufflation. Histological examination confirmed the biocompatibility of the formulation.

Fig. 2 Characterization of diatrizoic acid nanoparticle agglomerates (NA). (El-Gendy N.; et al. 2010)

References

El-Gendy N, et al. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. International journal of pharmaceutics, 2010, 391(1-2): 305-312.

Why is Diatrizoate Sodium important in contrast media development?

As one of the original ionic contrast agents, Diatrizoate Sodium serves as the historical benchmark against which newer low-osmolar and iso-osmolar agents are compared in safety and efficacy.

What storage conditions are required?

Should be stored at room temperature in a tightly sealed container, protected from light.

What purity grade is available?

Supplied as a high-purity grade suitable for medical imaging R&D and pharmaceutical manufacturing.

Can packaging be customized?

Packaging formats and order quantities are customizable upon request for R&D and production needs.