Dexbrompheniramine Maleate

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Cat Number

API2391039

CAS Number

2391-03-9

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Product Detail Description Customer Q&A

CAS Number

2391-03-9

EINECS

219-236-2

Storage

Under -20℃

Synonyms

(+)-2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridinemaleate

Molecular Formula

C20H23BrN2O4

Molecular Weight

435.3

Smiles

CN(C)CC[C@@H](C1=CC=C(C=C1)Br)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O

Appearance

White to off-white solid

Melting Point

132-134℃

General Description

Dexbrompheniramine Maleate is the dextrorotatory enantiomer of brompheniramine, a first-generation propylamine antihistamine. It exhibits approximately twice the antihistamine potency of the racemic mixture.

Mechanism of Action

Dexbrompheniramine competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated activation of phospholipase C signaling that triggers vascular permeability, smooth muscle contraction, and sensory nerve stimulation.

Application

Used in the symptomatic relief of allergic conditions. Dexbrompheniramine Maleate is indicated for seasonal and perennial allergic rhinitis, urticaria, angioedema, and allergic conjunctivitis.

What advantage does the dextrorotatory form offer over racemic brompheniramine?

The dextrorotatory enantiomer provides approximately twice the antihistamine potency of the racemic mixture, allowing lower dosing while maintaining equivalent efficacy.