Dandelion Root Extract

Cat Number

PIPE-0018

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Product Detail Description Scientific Support Customer Q&A

Storage

Store in cool and dry area

General Description

Dandelion Root Extract is a processed and concentrated extract from the root of the herbaceous flowering plant Taraxacum officinale. It is extremely rich in flavonoids, polysaccharides, phenolic acids, vitamins B, C, E, and minerals. Dandelion Root Extract is a natural rich source of minerals and Omega-3 fatty acids and supports a comprehensive approach to well-being and therapeutic care.

Mechanism of Action

The dandelion root extract has multiple mechanisms of action. The primary effects are related to free radical scavenging and anti-inflammatory dampening, due to the high flavonoid and polyphenol content. Dandelion root is also a source of inulin-type polysaccharides, which support gut microbiome modulation and digestive motility. The extract is also rich in sterols and terpenoids that support detoxification in the liver and have antimicrobial effects.

Application

Dandelion root extract is a common nutraceutical ingredient with uses for supporting the liver's detoxification function, for reducing water retention, and for supporting healthy digestion by relieving constipation. In topical applications, the extract can relieve dermatitis and other inflammatory skin conditions, and dry and scaly skin.

Dandelion Root Extract is the most abundant source of taraxasterol, triterpenoids, and high-molecular polysaccharides that are responsible for most of its reported bioactivities. Dandelion Root Extract selectively induces caspase-8/caspase-3-mediated apoptosis in human leukemia, melanoma and gastric cancer cells without harming normal lymphocytes.
Dandelion Root Extract suppresses proliferation, migration and lncRNA-CCAT1 expression in gastric (SGC-7901) and esophageal squamous-cell carcinoma, and represses PI3K/AKT, Ras/Raf/ERK and Wnt/β-catenin signaling, reversing epithelial-to-mesenchymal transition and lymphangiogenesis. In rodents, Dandelion Root Extract reduces LDL-C, TG and MDA, increases SOD/GPx, and attenuates non-alcoholic fatty liver, atherosclerosis and doxorubicin-induced cardiotoxicity by activating Nrf2/HO-1 and inhibiting NF-κB/NLRP3.

Fig. 1 The pharmacological value of dandelions. (Yan Q.; et al. 2024)

References

Yan Q, et al. The phytochemical and pharmacological profile of dandelion. Biomedicine & Pharmacotherapy, 2024, 179: 117334.

What are the benefits of Dandelion Root Extract for gut health?

It contains prebiotic fibers like inulin, which support digestion, relieve constipation, and promote a healthy gut microbiome.

What active compounds are in Dandelion Root Extract?

Key components include dandelion flavonoids, polysaccharides, phenolic acids, terpenes, sterols, and vitamins.

Can Dandelion Root Extract be used in dietary supplements?

Yes, it’s commonly used in supplements for detox, liver support, digestion, and as a source of vitamins and minerals.

How does Dandelion Root Extract benefit the skin in cosmetics?

It soothes irritation, provides antioxidants, and helps cleanse and refresh the skin.