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Dacomitinib

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Cat Number

API1110813314

CAS Number

1110813-31-4

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Product Detail

CAS Number

1110813-31-4

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Synonyms

PF-299804, PF-00299804, PF299

Description

Dacomitinib (PF299)(PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.

Molecular Formula

C24H25ClFN5O2

Molecular Weight

469.94

Smiles

COC1CC2NCNC(NC3CCC(F)C(Cl)C3)C2CC1NC(=O)\C=C\CN1CCCCC1

Relative Density

1.344

Standard

Facility GMP

Qualification

DMF

Purity

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