Cyclopamine

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Cat Number

PIPE-0561

CAS Number

4449-51-8

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Product Detail

CAS Number

4449-51-8

EINECS

628-058-8

Storage

Room temperature

Synonyms

11-Deoxojervine 11-Deoxyjervine Jervine, 11-deoxo-

Description

Cyclopamine is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog signaling pathway (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.

Molecular Formula

C27H41NO2

Molecular Weight

411.6

Appearance

White Crystal Powder

Melting Point

>235℃ (dec.)

Boiling Point

550.8℃ at 760 mmHg

Purity

HPLC≥98%，95%，80%