Clindamycin Palmitate Hydrochloride

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Cat Number

API25507044

CAS Number

25507-04-4

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Product Detail Description Advanced Innovations Customer Q&A

CAS Number

25507-04-4

EINECS

607-740-9

Storage

Under -20℃

Synonyms

Clindamycin palmitate HCl; methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio- 2-hexadecanoate-L-threo-α-D-galacto-octopyranoside,monohydrochloride

Molecular Formula

C34H64Cl2N2O6S

Molecular Weight

699.9

Smiles

CCCCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@H]([C@H](O[C@@H]1SC)[C@@H]([C@H](C)Cl)NC(=O)[C@@H]2C[C@H](CN2C)CCC)O)O.Cl

Appearance

White to off-white solid

Melting Point

141-143℃

Standard

USP

General Description

Clindamycin Palmitate Hydrochloride is an ester prodrug of clindamycin, a lincosamide-class antibiotic structurally related to lincomycin. It demonstrates excellent tissue penetration into bone, joints, and abscess cavities.

Mechanism of Action

Clindamycin binds irreversibly to the 23S rRNA of the bacterial 50S ribosomal subunit, blocking aminoacyl-tRNA accommodation and inhibiting peptide bond formation during protein translation.

Application

Used in the treatment of anaerobic and Gram-positive bacterial infections. Clindamycin Palmitate Hydrochloride is indicated for respiratory tract infections, osteomyelitis, intra-abdominal infections, and toxoplasmosis prophylaxis.

Clindamycin palmitate hydrochloride (CPH) 3D-printed tablets (printlets) was developed and optimized using selective laser sintering (SLS) technology. A Box-Behnken design evaluated the effects of laser scanning speed, microcrystalline cellulose (MCC), and lactose monohydrate (LMH) concentrations on printlet weight, hardness, disintegration time (DT), and dissolution. Laser speed significantly affected all responses; MCC significantly influenced hardness, DT, and dissolution; while LMH affected hardness and dissolution. The optimized formulation contained 7.5% LMH and MCC at 203 mm/s laser speed. Characterizations including FTIR, XRPD, DSC, SEM, NIR hyperspectroscopy, and micro-CT confirmed no chemical interactions, uniform drug distribution, partial conversion of crystalline LMH to amorphous form, and porous microstructure with porosity of 24–31%. Dissolution exceeded 79% in 30 minutes for all formulations.

Fig. 2 PLS concentration images of the printlets showing distribution of the drug. (Mohamed E M.; et al. 2020)

References

Mohamed E M, et al. Formulation optimization of selective laser sintering 3D-printed tablets of clindamycin palmitate hydrochloride by response surface methodology. Aaps Pharmscitech, 2020, 21(6): 232.

What advantage does Clindamycin offer over other protein synthesis inhibitors?

Clindamycin demonstrates superior tissue penetration into bone and abscess cavities and exhibits potent activity against anaerobic organisms.

What storage conditions are required?

Store at room temperature in a tightly sealed container, protected from light and moisture.

What purity grade is available?

It is supplied as a high-purity grade suitable for R&D and pharmaceutical manufacturing.

Can packaging and order quantities be customized?

Yes, both packaging formats and order quantities can be tailored to meet specific R&D and production needs.