cis-tert-butyl 4-fluoro-3-hydroxypiperidine-1-carboxylate

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Cat Number

INT1174020462

CAS Number

1174020-46-2

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Product Detail Description Customer Q&A

CAS Number

1174020-46-2

Storage

Store at room temperature

Synonyms

(3S,4R)-4-Fluoro-3-hydroxy-1-piperidinecarboxylic acid tert-butyl ester;tert-butyl (3S,4R)-4-fluoro-3-hydroxypiperidine-1-carboxylate

Molecular Formula

C10H18FNO3

Molecular Weight

219.25

Smiles

N1(C(OC(C)(C)C)=O)CC[C@@H](F)[C@@H](O)C1

Boiling Point

300.8℃

Relative Density

1.15

pKa

13.58

General Description

cis-tert-butyl 4-fluoro-3-hydroxypiperidine-1-carboxylate is a protected cyclic amino acid derivative featuring a cis-relationship between the Boc-protected amine and the tert-butyl ester.

Mechanism of Action

It serves as a rigid cyclic building block. The cis-stereochemistry dictates a specific geometric relationship between the two functional groups, which is critical for the biological activity of the final drug product.

Application

It is used in medicinal chemistry research for the construction of diversified compound libraries and for optimizing the efficacy of lead compounds targeting metabolic disorders.