Cinoxacin

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Cat Number

API0232165

CAS Number

28657-80-9

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Product Detail Description Customer Q&A

CAS Number

28657-80-9

EINECS

249-133-8

Storage

Store at room temperature

Synonyms

Cinobac; Cinoxacino; Cinoxacine; Cinoxacinum; DTXSID8022822

Molecular Formula

C12H10N2O5

Molecular Weight

262.22

Smiles

CCN1C2=CC3=C(C=C2C(=O)C(=N1)C(=O)O)OCO3

Appearance

White to off-white powder

Melting Point

210°C (dec.)

Boiling Point

517.2±60.0°C at 760 mmHg (Predicted)

Relative Density

1.6±0.1

General Description

Cinoxacin is a synthetic quinolone antibacterial agent, structurally related to nalidixic acid but with a dioxolo group fused to the quinolone ring. The molecule contains a 1‑ethyl and a 4‑oxo group, typical of first‑generation quinolones.

Mechanism of Action

Cinoxacin inhibits bacterial DNA synthesis by targeting DNA gyrase (topoisomerase II) in susceptible gram‑negative bacteria. It binds to the A subunit of gyrase, stabilizing the enzyme‑DNA complex and causing double‑strand breaks. The drug is bactericidal and exhibits concentration‑dependent killing.

Application

Cinoxacin was indicated for the treatment of uncomplicated urinary tract infections caused by Escherichia coli, Proteus mirabilis, Klebsiella species, and Enterobacter species.

Does Cinoxacin require protection from light during long-term storage?

Yes, it is photosensitive. UV light can cause photodegradation of the quinolone core. Store in light-resistant containers, preferably original packaging.

What is the recommended storage temperature for Cinoxacin?

Store at controlled room temperature (15-25°C). Avoid temperatures above 30°C, which accelerate decarboxylation and formation of the desfluoro impurity.