Chlorphentermine Hydrochloride

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Cat Number

API151064

CAS Number

151-06-4

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Product Detail Description Customer Q&A

CAS Number

151-06-4

Synonyms

1-(4-chlorophenyl)-2-methyl-propan-2-amine hydrochloride;(4-Chlorophenyl)-2-Methylpropan-2-aMine Hydrochloride

Molecular Formula

C10H15Cl2N

Molecular Weight

220.14

Smiles

CC(C)(CC1=CC=C(C=C1)Cl)N.Cl

Appearance

White to beige solid

Melting Point

234℃

General Description

Chlorphentermine Hydrochloride is the hydrochloride salt of chlorphentermine, a para-chloro substituted analog of phentermine, belonging to the phenethylamine class of sympathomimetic amines. The para-chloro substitution alters the pharmacokinetic profile compared to unsubstituted phentermine.

Mechanism of Action

Chlorphentermine Hydrochloride acts as a sympathomimetic amine that promotes release of catecholamines, particularly norepinephrine, from presynaptic nerve terminals in the hypothalamus and limbic system, producing anorectic effects through central adrenergic mechanisms.

Application

Historically indicated as an appetite suppressant for short-term obesity management. Chlorphentermine Hydrochloride is a para-chloro substituted phenethylamine sympathomimetic amine that promotes catecholamine release in the hypothalamus, producing anorectic effects through central adrenergic mechanisms.

How does the para-chloro substitution affect Chlorphentermine pharmacologically?

The para-chloro substituent significantly increases lipophilicity compared to phentermine, resulting in altered tissue distribution and retention valuable for structure-activity research.