Celastrol,Tripterin

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Cat Number

PIPE-0573

CAS Number

34157-83-0

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Product Detail

CAS Number

34157-83-0

EINECS

636-472-5

Storage

Room temperature

Synonyms

celastrol Tripterin Tripterine (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid

Description

An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM). It has a role as an antioxidant, an anti-inflammatory drug, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an antineoplastic agent, a Hsp90 inhibitor and a metabolite. It is a pentacyclic triterpenoid and a monocarboxylic acid.

Molecular Formula

C29H38O4

Molecular Weight

450.6

Appearance

Red powder

Melting Point

190-220℃

Boiling Point

645.7±55.0℃ (Predicted)

Purity

HPLC≥98%