Capmatinib 2HCl

1197376-85-4

Capmatinib 2HCl (INC-280 2HCl) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.Capmatinib 2HCl exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, Capmatinib 2HCl potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.

C23H19Cl2FN6O

485.34

Cl.Cl.CNC(=O)C1CCC(CC1F)-C1CNC2NCC(CC3CCC4NCCCC4C3)N2N1

1

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

DMSO: 11 mg/mL (22.66 mM)